Preregistration is great but even pre-registering isn’t a panacea. Pre-registered papers can still be silently dropped from publication so the macro paper-generating process still has an over-abundance of false positives if the negatives are dropped, and there can still be ambiguities in the analysis protocol where researchers can still impart influence over the results.

Are you familiar with p-hacking, or what some statisticians call the “garden of forked paths”? There are so many researcher degrees of freedom that go unreported and unconsidered. So much of academia is essentially encouraged to go on fishing expeditions until their data turns up something “significant”, and they probably don’t even have the statistics training to realize they’re doing unsound analysis.