this is such a difficult question to answer. some research suggest that it’s possible for permanent damage to be made from depression, while other’s suggest it is not permanent. this differs from mania, the opposite of depression, where we know that permanent damage is made with each manic episode

when someone is clinically depressed, their symptoms not only distort reality in a way, but their brain neurons and receptors are thrown off in some way. this ultimately leads to a decrease in some cognitive abilities