sa2bcity
sa2bcity t1_ja8wljh wrote
Reply to comment by TestTubeRagdoll in Is there a genetic disease where the heterozygote has more severe disease symptoms than the homozygote? by Altranite-
Yes, there are flaws with the article I referenced. There are other articles that suggest a more negative clinical course for homozygotes.
Squitieri, F., et al. (2003). Homozygosity for CAG mutation in Huntington disease is associated with a more severe clinical course. Brain, 126(4), 946–955. https://doi.org/10.1093/brain/awg077
sa2bcity t1_ja8x9in wrote
Reply to comment by fingawkward in Is there a genetic disease where the heterozygote has more severe disease symptoms than the homozygote? by Altranite-
You are right. In this case, however, the sickle-cell allele is the one that confers the advantage.