neuro__atypical

neuro__atypical t1_j1ne3oa wrote

Reply to comment by shawsome12 in Machine learning model reliably predicts risk of opioid use disorder for individual patients, that could aid in prevention by marketrent

There are novel and highly effective ways to treat pain being developed, like capsaicin injections, but development is moving at a snails' pace. Not enough money being put into it, probably.

There are also less novel treatments for pain like ketamine/esketamine, the latter being a nasal spray. But this isn't allowed to be used (regulatory red tape) even though it's safer than opioids. They won't let you take esketamine nasal spray home, it has to be administered at a clinic, and prescribing for pain is considered off-label use.

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neuro__atypical t1_ivpy51l wrote

Reply to comment by continentalgrip in New study (n=276) finds that a standardized mindfulness program is as effective as a common antidepressant (Escitalopram) at treating anxiety, with both treatments leading to about a 30% reduction in symptoms. by fotogneric

Sorry, I seem to have mixed up clinical and statistical significance. I was trying to respond to this part of your link:

> Even the small statistical difference between antidepressants and placebos may be an enhanced placebo effect, due to the fact that most patients and doctors in clinical trials successfully break blind.

Saying that it could be better explained by SSRIs' small but very real effect on BDNF (agents which promote BDNF to a much higher degree show actual clinically significant improvements in rats, e.g. Semax) than a hypothetical "enhanced placebo effect."

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neuro__atypical t1_ivpt4j7 wrote

Reply to comment by continentalgrip in New study (n=276) finds that a standardized mindfulness program is as effective as a common antidepressant (Escitalopram) at treating anxiety, with both treatments leading to about a 30% reduction in symptoms. by fotogneric

SSRIs' slight advantage over placebo could also be explained by their downstream effects on BDNF. Not everyone is responsive to BDNF/neurogenesis as a treatment for depression though, and the effects on BDNF are extremely weak compared to other neurogenesis-promoting drugs.

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neuro__atypical t1_ivpil5o wrote

Reply to comment by bekilledoff in New study (n=276) finds that a standardized mindfulness program is as effective as a common antidepressant (Escitalopram) at treating anxiety, with both treatments leading to about a 30% reduction in symptoms. by fotogneric

SSRIs are "effective," in the clinical statistical use of the term. But the effect size and success rate is very small compared to other drugs. They're pretty crappy.

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neuro__atypical t1_iu6b5j7 wrote

Reply to comment by SAYUSAYME007 in Exercise linked with increased longevity. Compared with just two minutes of vigorous activity per week, 15 minutes was associated with an 18% lower risk of death and a 15% lower likelihood of cardiovascular disease, while 12 minutes was associated with a 17% reduced risk of cancer by Wagamaga

exercise improves cognitive function and is likewise protective against cognitive deficits and dementia... nobody's doing it so they can live to 80 and be a borderline vegetable, they're doing it so they can feel better at 60 than they would otherwise.

bodily decline and actual lifespan are two very different issues. increased lifespan with decreased bodily decline is good.

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neuro__atypical t1_itms8kb wrote

Reply to comment by funkme1ster in Study finds brain changes associated with ADHD remission. As the brains of those with ADHD mature, some individuals may repetitively engage in strategies that compensate for symptoms. These repetitive behaviors may result in the brain changes seen in those who went into remission. by Wagamaga

You can take advantage of neuroplasticity for creating habits and behaviors to help you manage your deficits, but you can't neuroplasticity your way out of premature dopamine reuptake or low acetylcholine receptor density (two common properties of ADHD brains). The difference is important.

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