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magicfeistybitcoin t1_j4yqtid wrote
Reply to What's the current scientific consensus on resveratrol extending lifespan? by pixeleos
Eh. ConsumerLab calls the claims "exaggerated" and "even contradictory." Resveratrol activates the SIRT1 "longevity gene" associated with cellular metabolism, cellular repair, and lifespan. That's where the hype comes from.
The German study they cite re: longevity was small and involved obese mice "on an extremely high fat diet. Whether normally fed mice also show life extension by resveratrol remains unanswered." The high-fat diet mice had a 15% longer lifespan.
A 2017 Denmark study with humans is where the contradictory part comes in. High doses of resveratrol can lead to high total and "bad" LDL cholesterol levels and atherosclerosis. It inhibits an enzyme that metabolizes statins (which affect heart health). Low doses didn't have this effect, but no positive effect was found, either.
The website notes that many clinical studies are currently underway, but their comprehensive examination convinced me not to bother with it right now.