jimmypootron34
jimmypootron34 t1_j178fnt wrote
Reply to comment by Alaishana in In a randomized, double-blind, placebo-controlled crossover study 60% of insomnia patients "no longer classified as clinical insomniacs" after just 2-weeks of using medical cannabis oil by BoundariesAreFun
Your body does when melatonin is taken in large amounts, which it usually comes in unfortunately. The original literature described a dose of something like 5 micrograms, and usually it comes in doses of several milligrams. So that’s why it will definitely make you sleep but you also feel so groggy the next day, the amount is far more than what occurs internally. I don’t disagree though to some extent. Many treatments seem to have reduction in effect over time, but still effective. Or needs to have changes in dosage/time off if possible. I think it would help if people better understood the sort of diminishing returns nature of it. Try to find a place where the effectiveness is good even if not great, and the dosage doesn’t cause issues. Such as with melatonin I didn’t really like to use it because the typical dose comes with the grogginess and all of that, but at the dose it should be at that didn’t happen.
jimmypootron34 t1_j18mih3 wrote
Reply to comment by iwascompromised in In a randomized, double-blind, placebo-controlled crossover study 60% of insomnia patients "no longer classified as clinical insomniacs" after just 2-weeks of using medical cannabis oil by BoundariesAreFun
I would check that it’s a literature recommended dose. Melatonin, for patent reasons at least in the US from what I’ve read, often comes in amounts many times larger than what is produced endogenously. May be a bit late at this point but the dose recommended by actual data may also work well and not give any side effects like making someone totally dependent on it. I mean it doesn’t seem to be harmful even in these larger Doses, but I know it can be annoying to depend on something all the time.
Looked it up, the dose it’s supposed to come in based on the data is about 1/3 of a mg or 300mcg. Many come in about 3-5mg which is obviously many times more than that.