jadw87 t1_je9u1cm wrote on March 30, 2023 at 1:45 PM

Reply to comment by Andromeda321 in Gaia discovers a new family of black holes: astronomers studied the orbits of stars and noticed that some of them wobbled on the sky, as if they were gravitationally influenced by massive objects. No light could be found using several telescopes, leaving only one possibility: black holes. by Andromeda321

This guy black holes !!!

jadw87 t1_j9gttkl wrote on February 21, 2023 at 9:48 PM

Reply to comment by Maki1411 in Wombat cube-shaped poop is formed through an intestinal drying process akin to the dynamics of cooling lava beds, that create consistent cracks by marketrent

Yep...and because volcanoes !

jadw87 t1_iyztltl wrote on December 5, 2022 at 12:34 PM

Reply to comment by PoppersOfCorn in How can we see satellites? by CantaloupeForward898

I also have a son named Bort !

jadw87 t1_iy32f2r wrote on November 28, 2022 at 11:07 AM

Reply to comment by SpartanJack17 in Voyager images from the Jet Propulsion Laboratory (NASA) by Premium_Woman

Pardon my ignorance my good sir. Will it never get closer ?

jadw87 t1_iy1r73n wrote on November 28, 2022 at 2:11 AM

Reply to Voyager images from the Jet Propulsion Laboratory (NASA) by Premium_Woman

Voyager ?!?! Get J.W.S.T onto it ! Imagine how much more amazing...looks like you could walk on the rings

jadw87 t1_ixoc42f wrote on November 25, 2022 at 12:22 AM

Reply to Spotted an asteroid/meteor but there's nothing online about it? by OkLibrary6417

I seen a good one must have been travelling directly towards me because it didnt move much looked like was floating still in the sky, it was bright and then broke up...was wild

jadw87 t1_iu2nvbm wrote on October 28, 2022 at 2:32 AM

Reply to comment by jadw87 in Gut bacteria alleviate smoking-related NASH by degrading gut nicotine by chromoscience

Thank my need to find out what Nash is !

jadw87 t1_iu2nrye wrote on October 28, 2022 at 2:31 AM

Reply to Gut bacteria alleviate smoking-related NASH by degrading gut nicotine by chromoscience

Abstract

Tobacco smoking is positively correlated with non-alcoholic fatty liver disease (NAFLD)1-5, but the underlying mechanism for this association is unclear. Here we report that nicotine accumulates in the intestine during tobacco smoking and activates intestinal AMPKα. We identify the gut bacterium Bacteroides xylanisolvens as an effective nicotine degrader. Colonization of B. xylanisolvens reduces intestinal nicotine concentrations in nicotine-exposed mice, and it improves nicotine-exacerbated NAFLD progression. Mechanistically, AMPKα promotes the phosphorylation of sphingomyelin phosphodiesterase 3 (SMPD3), stabilizing the latter and therefore increasing intestinal ceramide formation, which contributes to NAFLD progression to non-alcoholic steatohepatitis (NASH). Our results establish a role for intestinal nicotine accumulation in NAFLD progression and reveal an endogenous bacterium in the human intestine with the ability to metabolize nicotine. These findings suggest a possible route to reduce tobacco smoking-exacerbated NAFLD progression.