bilyl
bilyl t1_ixxoyi6 wrote
Reply to comment by H2AK119ub in Brain cancer vaccine succeeds at prolonging survival in Phase 3 trial by Sorin61
I didn’t specify anything about whether newer drugs fall into this category, but it was very routine that older targeted inhibitors (especially kinase inhibitors like you said) were approved in the past 15 years (not that long ago!! I was in graduate school at that time) for very marginal benefits. So yeah, there are way better drugs now but drugs with marginal benefit were being approved “back then” because there was nothing better and because survival was really dismal.
bilyl t1_ixwgjia wrote
Reply to comment by H2AK119ub in Brain cancer vaccine succeeds at prolonging survival in Phase 3 trial by Sorin61
I’ll have to do a bit of research, but off the top of my head there are a couple of drugs that are in that range: Vemurafenib (metastatic lung cancer, ~3-4 months OS improvement), Crizotinib (~4 months), trodelvy (3.2 months for metastatic triple negative BC), trastuzumab (gastric cancer, <3 months), cetixumab (CRC, 1.5 months).
bilyl t1_ixw1apo wrote
Reply to comment by H2AK119ub in Brain cancer vaccine succeeds at prolonging survival in Phase 3 trial by Sorin61
Considering that there are plenty of oncology drugs that give one month of OS because of the dismal outcomes of specific cancers, this is a sure thing. Getting this data in a phase III trial just seals it.
bilyl t1_ixvskew wrote
Reply to comment by H2AK119ub in Brain cancer vaccine succeeds at prolonging survival in Phase 3 trial by Sorin61
This will for sure be approved shortly.
bilyl t1_ixvsg0d wrote
Reply to comment by bored_in_NE in Brain cancer vaccine succeeds at prolonging survival in Phase 3 trial by Sorin61
A little? You’re understating it.
bilyl t1_ixvsbzk wrote
Reply to comment by Common_Screen9450 in Brain cancer vaccine succeeds at prolonging survival in Phase 3 trial by Sorin61
There are therapeutic vaccines and prophylactic vaccines.
bilyl t1_ixt3cyp wrote
Reply to comment by me_and_myself_and_i in China's widening COVID curbs trigger public pushback by reuters
I think this is at the heart of the issue. The Chinese government knows that the health care system cannot handle COVID surges. Even with the camps and ancillary facilities, it wouldn’t be able to handle a “back to normal” approach.
China has billions of citizens in cities way more dense than the USA. Imagine what would happen if ICUs started to fill up…
bilyl t1_ixft01x wrote
Reply to comment by ozgun1414 in '1899': How the Mind-Bending Finale Sets Up More Story For Season 2 by Neo2199
There’s no point re-watching 1899 — it’s nowhere near as complicated as Dark.
bilyl t1_iu743ex wrote
Reply to comment by kedelbro in CNN Cuts Back on Original Series and Films by scuczu
They’re not. If you read the article it says they’re discussing making an in house division rather than 3rd party commissions.
bilyl t1_j4kndrg wrote
Reply to CNN Considers Content From Bill Maher, Warner Bros. Discovery Talent by exophrine
I thought the whole point of cancelling the docuseries and other shows was to get back to “real news”? And now they want a comedian on prime time? Talk about lack of vision.