When used properly there’s likely little to no negative long term effects

Taken in high doses you have liver issues with Tylenol and stomach/GI bleeding risk with Ibuprofen/aspirin

Low doses of aspirin reduce your risk of heart attack/stroke when taken daily and increase your risk of GI bleed

Some studies have shown a link between long term Tylenol use and early mortality, increased risk of heart attack, etc. however all these were observational studies with many confounding variables (for example someone who takes Tylenol daily is likely less healthy than someone who doesn’t need Tylenol daily so they may have a higher risk of death at baseline)

Basically if you don’t have any comorbidities or other risk factors and follow the directions on the package you’ll be fine and not experience any damages to your body. If you already have severe kidney or liver disease you probably should be more cautious

Oral is the most effected for reaching the liver. All those other administration techniques skip first pass metabolism which means they’ll go everywhere in the body THEN then liver while oral admin will go mouth>stomach>intestines>liver> rest of body