Sedating drugs can work synergistically as well, so while 100 mg probably wouldn’t be lethal in someone with significant tolerance if you add other sedating meds like diphenhydramine and cyclobenzaprine the overall level of sedation may push them over the edge.
Wyvernz t1_j6dxant wrote
Reply to comment by bynarie in Can you (roughly) determine the dosage of a drug taken based off of the blood concentration? by bynarie
Sedating drugs can work synergistically as well, so while 100 mg probably wouldn’t be lethal in someone with significant tolerance if you add other sedating meds like diphenhydramine and cyclobenzaprine the overall level of sedation may push them over the edge.