SelarDorr
SelarDorr t1_j7kbdrz wrote
Reply to comment by SaltZookeepergame691 in Analysis showed that 65.6% of women who took extra Vitamin D gave birth naturally. The study analysed results from the MAVIDOS trial which involved 965 women being randomly allocated an extra 1,000 International Units (IU) per day of vitamin D during their pregnancy or a placebo. by Wagamaga
the hypothesis exists when you decide what your secondaries are.
SelarDorr t1_j7j3uvk wrote
Reply to comment by leplen in Analysis showed that 65.6% of women who took extra Vitamin D gave birth naturally. The study analysed results from the MAVIDOS trial which involved 965 women being randomly allocated an extra 1,000 International Units (IU) per day of vitamin D during their pregnancy or a placebo. by Wagamaga
There are statistical tests for multiple hypothesis testing
SelarDorr t1_j7ilxie wrote
Reply to comment by SaltZookeepergame691 in Analysis showed that 65.6% of women who took extra Vitamin D gave birth naturally. The study analysed results from the MAVIDOS trial which involved 965 women being randomly allocated an extra 1,000 International Units (IU) per day of vitamin D during their pregnancy or a placebo. by Wagamaga
i dont see that as a major caveat. you can have a primary study with multiple secondary outcomes, in which the results of the secondary outcomes are just as meaningful as a study in which those outcomes are the primary.
the results of this analysis are still of a randomized double blind placebo controlled trial that directly compared the treatment group to the placebo group for the outcome in question. the fact that these results were not the primary focus of the study does not change its significance.
if it were a case where sample selection for the primary outcome somehow added a confounder for some of the secondaries, i see an argument there. but as far as i can tell, this wasn't the case here.
SelarDorr t1_j7ilh7a wrote
Reply to Analysis showed that 65.6% of women who took extra Vitamin D gave birth naturally. The study analysed results from the MAVIDOS trial which involved 965 women being randomly allocated an extra 1,000 International Units (IU) per day of vitamin D during their pregnancy or a placebo. by Wagamaga
why would you write a title like this, with the percentage of natural births for the treatment group but not the control? Has much less meaning as an empirical number in my opinion.
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the placebo group was 58%, resulting in a relative risk ratio of 1.13.
SelarDorr t1_j7kd890 wrote
Reply to comment by SaltZookeepergame691 in Analysis showed that 65.6% of women who took extra Vitamin D gave birth naturally. The study analysed results from the MAVIDOS trial which involved 965 women being randomly allocated an extra 1,000 International Units (IU) per day of vitamin D during their pregnancy or a placebo. by Wagamaga
i see, thanks