I think there is a perception that there is demand based on one or two massively popular games and a lot of the similar releases are "me too" efforts that want to steal share away in a saturated market and many ultimately fail and shut down after making a loss or barely breaking even.

The bemoaning of all these releases, many of which fail in an effort to grab share away from established games, is because money is being wasted developing a lot of these that could have gone I to under served gaming niches instead and probably made as much or more money.

Not infinitely no, but then we also don't have infinite compounds we can potentially use and the constraint that it not kill a patients cells means that it must be possible for some life to adapt to survive it meaning potentially the bacteria can. I'd say in practical situations it will be impossible to develop something bacteria can't adapt to.