PandaExpress3d t1_j4gvvyb wrote on January 15, 2023 at 5:22 PM Reply to How do the new generation of weight loss drugs (Semaglutide, tirzepatide) work and why are they seemingly so effective? by harpoonhambone Adding on to the mechanism: Insulin has negative feedback on release of ghrelin, which is the hormone responsible for appetite. So GLP-1 agonist causes release if insulin which decreases amount of circulating ghrelin = you aren’t hungry. Permalink 21
PandaExpress3d t1_j4gvvyb wrote
Reply to How do the new generation of weight loss drugs (Semaglutide, tirzepatide) work and why are they seemingly so effective? by harpoonhambone
Adding on to the mechanism: Insulin has negative feedback on release of ghrelin, which is the hormone responsible for appetite. So GLP-1 agonist causes release if insulin which decreases amount of circulating ghrelin = you aren’t hungry.