To add to what others have said, your immune system isn't responsible for handling changes in bodily chemistry, be it through hormones or otherwise. They can overreact to more complex molecules such as proteins because bacteria, viruses, and other cells use proteins for receptors. And really, that's mostly the class of molecules they look for. Proteins and lipids.
So what is responsible for handling drugs, toxins, and other molecules? Your liver. There are other organs involved but anything that isn't reduced to salts or other excretable molecules goes through the liver to be handled. The liver itself has a limited capacity to handle substances, so what drugs effectively do is exceed the liver's capacity to break them down in time before they can act on your body in the intended way. With multiple circulations of your blood, your liver will eventually catch the rest.
OrdinaryProper6865 t1_itk0xns wrote
Reply to Why don't drugs provoke an immune response? by parrotlunaire
To add to what others have said, your immune system isn't responsible for handling changes in bodily chemistry, be it through hormones or otherwise. They can overreact to more complex molecules such as proteins because bacteria, viruses, and other cells use proteins for receptors. And really, that's mostly the class of molecules they look for. Proteins and lipids.
So what is responsible for handling drugs, toxins, and other molecules? Your liver. There are other organs involved but anything that isn't reduced to salts or other excretable molecules goes through the liver to be handled. The liver itself has a limited capacity to handle substances, so what drugs effectively do is exceed the liver's capacity to break them down in time before they can act on your body in the intended way. With multiple circulations of your blood, your liver will eventually catch the rest.