Well, yes and no. There are certainly points of separation beyond which interbreeding either doesn't happen, extremely rarely happens, or results in a non-viable offspring.

This is one of the reasons I brought up the topic of ring species. They demonstrate an entire spectrum of interbreeding specimens, the ends of which either do not or cannot interbreed despite living in the same location.

There is only one "objective" point of differentiation between "micro" and "macro" evolution: speciation.

But given that we have observed speciation events, and that ring species exist, it's pretty safe to say that macroevolution occurs.