AnnexBlaster

AnnexBlaster t1_jaqddst wrote

Reply to comment by va_str in US public investment in critical research contributed to the success of mRNA Covid vaccines, and saved millions of lives by geoxol

If the government wants to accelerate research it has to tax more. Its also getting less taxes from biotech/pharm companies because they cant make profit.

In order to bridge this gap the government needs to make money from somewhere (taxes) or no research will be funded.

The US government cannot print money forever without raising taxes.

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AnnexBlaster t1_jaobkkz wrote

Reply to comment by va_str in US public investment in critical research contributed to the success of mRNA Covid vaccines, and saved millions of lives by geoxol

How can companies improve current drugs or research new technologies if they dont make profit? How can the government afford to fund research in biomedical science if it doesnt get any profit from taxes?

This means that in a government only funded research world with no “profit”, the “profit” to conduct research will be taken from tax payers.

Literally at the square one again, the only benefit is less price gouging, but theres less freedom in research. And clinical trials still cost billions of dollars.

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AnnexBlaster t1_j7yevf3 wrote

Reply to comment by BuggerMyElbow in According to a study on 12,211 patients, aspirin is just as effective at preventing blood clots as low molecular weight heparin, but it costs less and is easier to administer by giuliomagnifico

Theres proteins in Staph aureus called clumping factors which active platelets, and pore forming exotoxins called alpha hemolysins which cause major damage.

Sepeis varies a great deal between bacteria, the toxins from different pathogens determine whether your immune system will win, or how fast and painful your death will be

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AnnexBlaster t1_j7wmgtr wrote

Reply to comment by Hapgam in According to a study on 12,211 patients, aspirin is just as effective at preventing blood clots as low molecular weight heparin, but it costs less and is easier to administer by giuliomagnifico

Yes I do research on the effects of anticoagulant drugs for sepsis, but I haven’t investigated aspirin yet, I suspect though that the toxins in sepsis cause far too much platelet activation for aspirin to handle, ticagrelor on the other hand looks very promising for increasing platelet killing efficiency and host survival.

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AnnexBlaster t1_ivs1tmr wrote

Reply to Does the dna of transplanted organs (organic material) change after the recipient successfully recovers? by theZoid42

No the DNA does not change. The DNA cannot change unless there is genetic engineering happening like CRISPR. (Or random mutations)

There are things called retrotransposons (LINEs) that are able to move DNA but these are rarely expressed and as far as I know they are only intercellular and don’t move between cells.

But think about it, in an organ there’s hundreds of thousands to millions of cells each with their genome. The genome can not change on this scale, it is evolutionarily disadvantageous for a genome to be able to change that much (could lead to cancers and overall disfigurement of the proper transcription profile that the specific cell needs to function).

As others have said, organ transplant recipients need to take immunosuppressive drugs because the immune system recognizes the organ is not self. Doctors try to match the HLA profiles (the main receptors immune cells use to recognize self) so that as little rejection happens as possible, but it’s still not enough in many cases.

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