Hello Mr Hunt,
I am curious what you think of this real condition: 35 years old male, has thrombosis in left popliteal artery, with total occlusion, extending down for 11cm. Smoked for 9 yrs, alcohol used, condition worsened after heavy depression and pandemic period but started long before (at least a year before pandemic). Was failed to diagnose in Europe, finally diagnosed at 4th of August 2022 in turkey. Never had covid during this time.
He has MTHFR hetorozygot and 4G/5G allelles from thrombophilia genetic tests. Do you think it may be buergers?
The hematology docent thinks the mutations could be contributing at least, He also has mild hyperhomocysteinemia. I repeat another user's question here, is homocysteine testing also unnecessary? Could it be harmful to try to lower homocysteine with b vitamins and folic acid?
Sorry that's too many questions in one comment, it's not often to find a hematology professor with time to answer! All my questions are out of curiosity rather than trying to prove otherwise. Thank you for your time! Have a nice day!
AlbayCorc t1_irs0led wrote
Reply to AskScience AMA Series: I am Prof. Beverley Hunt, OBE, and I am a hematologist in London, England. I am also chair of the World Thrombosis Day Steering Committee. I am here to talk about why MTHFR testing is unnecessary and can cause misinterpretation. AMA! by AskScienceModerator
Hello Mr Hunt, I am curious what you think of this real condition: 35 years old male, has thrombosis in left popliteal artery, with total occlusion, extending down for 11cm. Smoked for 9 yrs, alcohol used, condition worsened after heavy depression and pandemic period but started long before (at least a year before pandemic). Was failed to diagnose in Europe, finally diagnosed at 4th of August 2022 in turkey. Never had covid during this time.
He has MTHFR hetorozygot and 4G/5G allelles from thrombophilia genetic tests. Do you think it may be buergers? The hematology docent thinks the mutations could be contributing at least, He also has mild hyperhomocysteinemia. I repeat another user's question here, is homocysteine testing also unnecessary? Could it be harmful to try to lower homocysteine with b vitamins and folic acid?
Sorry that's too many questions in one comment, it's not often to find a hematology professor with time to answer! All my questions are out of curiosity rather than trying to prove otherwise. Thank you for your time! Have a nice day!