Not really, they're only there to have a good time. Your options are (a) ignore them and keep walking and (b) join them.

The entire street is lined with bars and clubs, you have your pick of vibe, level of crowds, type of music and amount of underage drinking.

My band frequently plays at either Bossa or Green Island (both along 18th street). At Bossa we get people who are there to dance, they get a few drinks but are chill and fun; at Green Island about midnight we start getting 19-year-old girls barely able to stand