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GeneralNathanJessup t1_j2cotfv wrote

Reply to comment by IAmDavidGurney in TIL that the drug GHB occurs naturally and is produced as a result of fermentation, and is found in small quantities in some beers, wines, beef, and small citrus fruits. It is also produced in the human brain by IAmDavidGurney

The brain has nicotine receptors. https://www.sciencedirect.com/topics/medicine-and-dentistry/nicotinic-receptor#

The brain has opiate receptors. https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/opiate-receptor

The brain has cannabinoid receptors. https://www.labroots.com/trending/videos/12752/thc-binds-cannabinoid-receptors-brain

Most drugs work by mimicking the brains own chemicals.

Another interesting fact. The industrial solvent named 1,4 butanediol is converted by the human liver into GHB.

1,4 butanediol is not a federally controlled substance, and is not covered under the Federal Analog act. https://en.wikipedia.org/wiki/1,4-Butanediol

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IAmDavidGurney OP t1_j2cqtt4 wrote

Yes, but I meant that the GHB receptor is there to have endogenous GHB bind to it. Nicotinic acetylcholine receptors are designed to have acetylcholine bind to them. Nicotine binds to them but the receptor isn't there for nicotine since it isn't naturally in the brain. Opiate receptors are there to have endorphins bind to them, not exogenous opioids. Cannabinoid receptors are meant for endocannabinoids like anandamide, not THC.

Yeah, these drugs bind to those receptors but the receptors are there for naturally occurring neurotransmitters, not the drug. What's interesting about GHB is that its receptor is designed for the brains GHB.

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