I was on Accutane for 6 months. It dries your face out to the point where little bits of your face come off. Someone called me the ugliest person they had ever seen during that time. I could see how you would want to kill yourself regardless of any effect on brain chemistry. Six months later, at 16 years old, I’m making out with the hottest girl of this new group my friends met in a closet at a party. My face completely cleared up. I had pretty bad acne and Accutane changed the trajectory of my high school life. I’m glad that it existed when I was in high school, despite the side effects.