Just because you can give an amazing performance doesnt mean all the showrunners in Atlanta or Hollywood want you.

Theres also the fact 40s to 50s something roles are typically going to be playing a dad, not playing a main character anymore.

Big talent can also burn you if a movie obligation/ the mouse calls.

Emily VanCamp was a main character and steady romantic partner of another main character on The Resident. But when the mouse called her back to marvel its not like she's saying no.