Lost is absolutely worth watching, but your enjoyment will vary depending on a few factors:

1. Are you able to watch the show while giving it your full attention? If you watch it in the background or while on your phone, you're very likely to miss something, be it foreshadowing, a character connection, a lore detail, an answer to a mystery, etc. It's not easy to get lost watching the show if you're paying full attention to it, but it's apparently very easy to get lost watching the show if you're only half paying attention to it.

2. Do you hate shows that have any reference to religion whatsoever? This is particularly important because Christianity, Islam, Judaism, Buddhism, Taoism, and more eclectic religions are all referenced throughout the show. Sometimes they're very important to the characters. Sometimes they explain how a character will react to and interpret certain sci-fi weirdness that they encounter. A lot of people I know who watched and hated the show did so because they can't stand any reference to religion in a show, and there is a decent bit of it in Lost. This has also influenced how some audience members interpret the show (for better or worse). For example, there is a particularly iconic scene from the show that takes place in a religious setting, and lore is explained at this setting. Because of the setting, some people interpreted the explained lore through that religion's popular mythos even though the show never said that the lore being explained adhered to that religion's mythos.

3. Related to the above, are you able to use the information a show gives you to determine what is true despite character interpretations to the contrary? The show answers most mysteries that it presents, but certain characters interpret those answers through a limited point of view and understanding. As such, if you stick to just the characters' interpretations of those answers rather than the full answer that the show gives you through various avenues, you may find the "answer" as interpreted by the characters disappointing or contradictory even though the show has explained that the characters' interpretation is just an interpretation, not the full answer.

4. Are you one to theorize on your own as the show progresses? If so, don't let yourself get married to any of your theories as that led to a lot of disappointment in people. That said, I do encourage you to really think about and try to figure out what's going on as you watch it as that's part of the fun and will make the reveals make more sense since you've been giving the mysteries thought as the show progresses.

5. Do you need the answers spelled out for you, or are you okay inferring the answers? For example, at a certain point the show may say "Here's a mystery, and the answer is either A, B, or C." Then a season later it'll say "The answer to that mystery isn't B." Then a season later it'll say "The answer to that mystery isn't C." And then it'll never reference the mystery again. You'll just have to know from inference that the mystery was answered, the answer was A, but the show didn't need to come out and say that to you explicitly because it explained how the answer couldn't be any other possibility.

6. Are you okay with answers being sci-fi in nature rather than being super grounded in real life? While everything in the show that is answered could be argued to work via a real world branch of science or pseudoscience, some of them are stretched to sci-fi limits. Basically if you don't mind lightsabers and teleporters where there is a "science" to explain things even though that science wouldn't actually work in real life, then you're going to be fine. The answers may seem like "the Force" at certain points where there is no real scientific answer, but everything in the show can be argued and interpreted through a hard sci-fi lens. You don't need to interpret any of it through a fantasy/sci-fi lens (though it is easier for some people to swallow some of the answers that way).

If you keep those things in mind and don't have an issue with any of them, you should absolutely give the show a shot. Watch the two-part pilot. If that doesn't hook you but does interest you, watch through 1x04 "Walkabout". If that doesn't hook you but you're still interested in the show, watch through 1x10 "Raised By Another". If you're still not hooked on the show by that point, the show may just not be for you.

But do your best not to look up anything about the show as you watch because spoilers are everywhere.

Also, there are a number of canon pieces of the show that are found through webisodes and the like, so if you want to watch these extra parts of the show, let me know and I'll send you a list/links to the extra parts as well as when to watch them to get the full experience of the show.