Viewing a single comment thread. View all comments

asraniel t1_j4akx1j wrote

did they ever test this on mice that were not aged artificially? i should probably read the paper, but i always read about this in the context of artificially aged mice. my question is if the artificial aging is really equivalent to real aging and thus if the reversing works on both the same.

67

Deathbeddit t1_j4argko wrote

(Only from article, not paper) They used artificially aged mice. Much salt from me, too.

34

retrohGamr t1_j4co3p9 wrote

okay but what is artificially aged mice?

i agree, they should just use AGED mice, but i feel artificially aged when going through stressful and traumatizing events. if they're inducing aging in a similar fashion i still think it's conducive to their goal as curing the wear and tear that comes from stress and environment could be a huge market.

13

johnwayne2413 OP t1_j4auwmu wrote

https://www.reddit.com/r/science/comments/10al6z7/-/j455c7w

"All living things experience an increase in entropy, manifested as a loss of genetic and epigenetic information. In yeast, epigenetic information is lost over time due to the relocalization of chromatin-modifying proteins to DNA breaks, causing cells to lose their identity, a hallmark of yeast aging. Using a system called “ICE” (inducible changes to the epigenome), we find that the act of faithful DNA repair advances aging at physiological, cognitive, and molecular levels, including erosion of the epigenetic landscape, cellular exdifferentiation, senescence, and advancement of the DNA methylation clock, which can be reversed by OSK-mediated rejuvenation. These data are consistent with the information theory of aging, which states that a loss of epigenetic information is a reversible cause of aging."

The paper is more detailed.

https://www.cell.com/cell/fulltext/S0092-8674(22)01570-7

32

Bupod t1_j4elihp wrote

Ok but how can I be stupid and do this on myself in my garage with a double digit IQ and the scientific skill of a squirrel?

14

Much_Highlight_1309 t1_j4cw8wg wrote

I understood that they reversed eye sickness in aged mice. I didn't read that as them being artificially aged mice but I would need to read the original publication to confirm my understanding.

5