Available in 15 years, if ever.

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Simple answer - as a diabetic I am sick of these "fantastic development" articles. Raised hopes slowly dwindling int dust.

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I see you're not familiar with Type1 diabetes.

>Just eat less damn sugar.

r/ThanksImCured

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Well, only if they can overcharge by 5million percent every year. And only if they can keep it to suppress any cures. More money in maintenance.

The next step will be to make this, or something similar, glucose-sensitive. Unfortunately a molecule that will always be around/active in the blood mimicking insulin isn’t really that useful, as it would cause a crazy amount of hypoglycaemia. Hence why we need something that will only become active/more active in the presence of glucose.

Yay, another thing for Americans to be unequivocally unable to afford

Amen to what you are saying !

Short half life and dose dependent just like insulin you mean?

While we argue about this we are quickly bringing Biologics (synthetic antibodies) to market that will effectively greatly reduce or eliminate diabetic complications.

The issue is going to be that big pharma will want thousands of dollars a shot (with a shot lasting a few months), leading to insurances not wanting to cover it.

A pill would be already an improvement or?

Insurance will cover it if it is cheaper than expected long term costs of not having the shot. Paying $10k a year (after you pay the first $5k deductible of course) is lot cheaper than paying for long hospital stays, limb amputations, and other infection related issues.

I’m sure the companies making the shot will set the price to just below the calculated long term costs of not getting the shot.

That’s the “joy” of privatized medicine. Pharma companies set high prices, to suck as much money from insurance as they can. Hospitals set high prices to suck as much money from insurance (and patients) as they can. Then the insurance companies set prices to suck as much money from people as they can.

Executives everywhere get rich and the public all gets poorer and gets poor access to healthcare that costs too much.

Lets see:

• Option 1: Doctors provide plans for patients to reduce their carbohydrate intake, pushing their diabetes into remission; or
• Option 2: Doctors listen to pharma reps that "this is the next big thing", they ceate another billion or 2x or 3x Billion pill and patients continue treating diabetes as a progressive disease that slowly takes toes, feet, eyes and legs.

What'll it be Jimmy? Door number 1 or door number 2?

I really hope this is used for the general public and not just the well connected.

You realize Type 1 is genetic and isn’t created by dietary habits?

95% pf suffers are T2. Diabetes used to be 1% of the population and almost exclusively T1.

Not to mention insane profits for whomever has cooked up this 'miracle'.

yep theyve been promising cures for all sorts of diseases for the past 15 years

Yes, it is. If you use long acting insulin you run the risk of hypoglycemia if you don’t eat enough. If you take too much fast acting insulin you could die. You’re supposed to know how much you need or eat according to how much you injected. Regardless, it is an improvement. What the comment above mine says just sounds impossible.

darn tootin' brother, that's why I only take the finest supplements from Alex Jones instead of going to those fake leftist medical doctors and their big pharma overlords

That's being actively developed right now.

https://bristol.ac.uk/news/2018/august/ziylo-deal.html

All approved drugs are available to the public 😂

Yeah, and this is the same fantasy island where you think that those affected will suddenly and consistently change their dietary habits.

Diabetics hear about such advancements ALL OF THE TIME. It's a newar constant barrage of new super effective treatments or cures that are always "5-10 years away".

It is fair to be skeptical.

No, that is flat out untrue. Type 2 has always been more common. Especially when you consider that type 1 was a quick death sentence up until a hundred years ago. And around 20% of type 2 patients develop it without obesity or diet as a contributing factor. At least in the US. That ratio is higher in countries with less obesity. For example just getting old is a major contributor too, as well as just genetic predisposition.

No because insulin is about timing. You take insulin in response to a meal. If you just pop a pill in the morning, there’s nothing to tell the mimetic to begin or stop acting.

Yeah I worked for a company that was producing one but it didn’t work so the project was shuttered. Hopefully someone can sort it out.

When 10 years from now? Well connected first then regular people. I don’t put that much faith in humanity, especially after a medical breakthrough. $$$$$

In the 70s total diabetes as a measure of population was 1%. Its now over 10% and can you guess what type has been the main "lifestyle" disease?

Type 1 was never a death sentence. The original "treatment" was ... low/no carb in the 1800s.

But that's besides the point, Diabetics are never even told that they can restore insulin sensitivity and/or put the disease into remission. Its just more pills and injections.

Holy shit man, that's not how any of it works. If its approved, its approved, and anyone has access to it provided they are medically eligible. It will cost money though.

Isn't cinnamon extract basically doing this (for mild diabetes sufferers)?

I hope this is sarcasm

many people are also able to control T2DM with only basal insulin (i.e. long acting insulin that isn’t bolused at meals)

it’s impressive how inaccurate you’re able to be in so few comments!

There’s a reason we regularly do pre-diabetes screening and education… and why we focus so much on lifestyle changes during the reversible period of T2DM.

Well, for those of us who live under the socialist iron fist of universal healthcare this is great news at least.

Reversible period? If pancreatic function is still present, its a question of restoring insulin sensitivity. Which is still best achieved wth ... low carbohydrate diets. Turns out the thing which overloaded the system aka glucose is the same thing we can remove from the diet to restore it.

So, we should stop developing drugs?

Do you actually think that the was the point of the statement?

You’re looking for an argument. In a weird place. Why?

No, it's a criticism of our For Profit Healthcare System. Specifically, how fantastically expensive insulin already is

Again, flat out untrue. Until the isolation of insulin by Banting and Best, the best you could do was extend life. Cutting carbs alone would give you a few months or a couple of years if your "honeymoon period" lasted longer. Because even fat/protein intake affects blood glucose (to a lesser extent than carbs), many people also followed the "starvation diet", which extended life longer by consuming the absolute bare minimum of calories. It always resulted in death though.

Yes, as I clearly implied, type 2 prevalence has increased a lot due to lifestyle but it has always been more prevalent than type 1. Another major contributing factor is age and people are living longer.

No one’s arguing against low carb diets being effective in managing T2DM. However, your assessment that eliminating sugar from a diet will reverse T2DM is only accurate in early stages of the disease.

At some point, insulin insensitivity cannot be reversed with lifestyle changes alone, and is certainly not “best achieved” with such changes.

This should make insulin cheaper right?

• Anakin smirk

twiddles thumbs for another 30 years

So what will eventual market prices be? And how long will a shot last? What of insurance cover? All these seem nice on paper till we come to real life scenarios and we realize big pharma isnt our friend

Insurance companies may cover it if it is cheaper than expected long term costs of not having a shot.

I can’t tell you how many teach patients get one suction set up per month to clear their trachs and keep getting hospitalized with recurrent tracheitis and respiratory tract infections (upper and/or lower). Suctioning is a routine procedure that is done aseptically (sterile gloves and equipment) multiple times a day in a clinical setting, with all new equipment each time.

Assuming companies are smart with their money is not always a safe bet.

You have a lot of nerve asking stupid questions after what you did on Eros.

Develop a new flu virus that leaves everyone with diabetes. Super contagious asf. Then they will be forced to work on this and release it to the masses for free as a vaccine.

As a diabetic, Multiple Sclerosis, liver and kidney disease patient (with just a dash of eczema for spice) I'm amazed at the continuing development and release of new tested and safe therapies.

Trulicity and Ocrevus immediately spring to mind.

“Research findings have been mixed, and the American Diabetes Association dismisses cinnamon’s use in diabetes treatment.” It also can have negative interactions with other medications and supplements.

I FUCKING LOVE THIS REFERENCE

I always wondered why we don't use the gut biome with bio engineered bacteria to release insulin and other needed drugs

Metformin is a really low cost drug right now, so the insurance companies will have "step therapy" meaning you need to fail with the "frontline therapy" to qualify for possible coverage of more expensive alternates.

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Too bad Type 1 diabetics don't produce insulin regardless of diet and fitness level.

Why would you jump to this conclusion rather than "lets try and make them cheaper"?

Sure. But type two diabetes is progressive and almost all those patients will eventually fail because of the nature of their disease. What will make this drug useful is if it was the only thing required, aka a short acting insulin mimetic, which will actually regulate blood sugar in an impressive way. Most type 2s on long acting are also on other oral antidiabetic medications because long acting just doesn’t really lower blood sugar a whole bunch.

Source: I’m a type 1 diabetic, did my PhD in metabolic disease, and worked in research for a large pharmaceutical company in their diabetes portfolio.

The trouble is, if your doctor says you need the shot every 3 months, the insurance company will only cover it once every 6 months, and when you get an exception written up by your doctor they'll still deny the request. When a generic comes out that isn't as effective, they'll force you to switch, again against your doctor's orders.

People focus on how expensive healthcare in this country is because of this broken system, but to me the crazier thing is how much your insurance company can dictate how your doctor treats you.

You ignorant asshole that’s not how diabetes works.

I wonder if more options will bring prices down. One can only hope

bolus insulin (short acting) is about timing, but basal insulin (long acting) is a once a day thing (twice in some cases), where you always have some insulin circulating. All type 1's need this, and type 2's use it in some cases too.

Have you met humans? Just saying, it’s gonna be some regular Joe/Joanna denied the treatment. THEN after the lawsuit it will be available. I’ve worked in the industry and this is how it really goes. Gattaca-light type BS

Not all type 1s need long-acting insulin. For example, those on pumps. Because the short acting is delivered throughout the day and night. Theoretically this drug could be designed to fulfill both roles, if they made it glucose sensitive.

You're a special kind of stupid.

Never underestimate the ability of big pharma to profit from our deaths

A special kind of stupid that has actually helped Diabetic before.

You do not work in the industry, this is clear. The entire concept you're suggesting is fucking ridiculous, to be honest. It's simply, flatly, untrue. If you medically qualify and have the means to pay via insurance or rich daddy, you get it. Period.

​

Take the dystopian bullshit elsewhere.

Straw man much?

This is true. Took metformin, couldn't tolerate some bad side effects, now have a much more effective drug to take AND I get to take it much less frequently then metformin.

Maybe not. I take a synthetic hormone daily which 100's of millions of people worldwide depend on. It has been on the market for more than 30 years.

And it costs only $10 cash out-of-pocket (no insurance) for a 90 day supply - cheaper than one lunch at a fast-food restaurant.

Market competition can produce remarkable results.

5 years away…

While you're technically correct on the pump, the pump itself is manipulating the insulin delivery to mimic long acting insulin so that's only a semantic difference. Whether it's a constant drip from a pump or a constant release from injected basal insulin, all type 1s need a constant delivery of insulin.

Thanks Dr. Jayhasbigballs

Ok whatever let’s see who gets it

Seriously? Here's some FaCts:

Type 2 diabetes accounts for approximately 90% to 95% of all diagnosed cases of diabetes; type 1 diabetes accounts for approximately 5-10%

Source: https://www.cdc.gov/diabetes/basics/quick-facts.html

And type 2 diabetes can be put into remission at any stage of the disease, or do you think there is only one path: ever increasing insulin shots, amputation and death?

In the event that this is approved years from now, I'll save you the suspense: Everyone who medically qualifies and has the means to pay.

ah another levothyroxine dependent

Nahh wealthy communities first others old combos

Again, none of that in any way contradicts what I said earlier.

To quote you directly:

>Diabetes used to be...almost exclusively T1.

I'm talking about that part. Type 2 has ALWAYS been the more prevalent type. Always.

And no, it absolutely cannot be put into remission for all patients. There are some people with completely healthy diets, weights, and exercise regimens that still develop the disease. They are absolutely the minority. I am not disputing that. But you're flat out wrong to claim that doesn't happen. Or that type 1 used to be more prevalent than type 2. Or that people could survive long term with type 1 with lifestyle changes alone before insulin was available. Those are all 100% incorrect statements that you've made.

You’re a fool 😂

Now you know and knowing is half the battle

For a decade, then India makes generic versions

The thing OP doesn't understand here - insurance companies may not want to cover it depending on how long term of a cost it is. If there's a chance that they're the ones holding the bag at the end, then they'll happily cover it.... but if the complications of it won't rear its head until 20 years later... they'll gamble that someone else will be left holding the bag when it comes time to pay up.