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TummyDrums t1_j0zgs5x wrote

Reply to comment by jayhasbigvballs in Molecule that mimics insulin opens new doors for a diabetes pill by rchaudhary

bolus insulin (short acting) is about timing, but basal insulin (long acting) is a once a day thing (twice in some cases), where you always have some insulin circulating. All type 1's need this, and type 2's use it in some cases too.

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jayhasbigvballs t1_j0zihvh wrote

Not all type 1s need long-acting insulin. For example, those on pumps. Because the short acting is delivered throughout the day and night. Theoretically this drug could be designed to fulfill both roles, if they made it glucose sensitive.

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TummyDrums t1_j0zxetd wrote

While you're technically correct on the pump, the pump itself is manipulating the insulin delivery to mimic long acting insulin so that's only a semantic difference. Whether it's a constant drip from a pump or a constant release from injected basal insulin, all type 1s need a constant delivery of insulin.

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