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anormalgeek t1_j0ypshf wrote

Reply to comment by anonprogtada in Molecule that mimics insulin opens new doors for a diabetes pill by rchaudhary

No, that is flat out untrue. Type 2 has always been more common. Especially when you consider that type 1 was a quick death sentence up until a hundred years ago. And around 20% of type 2 patients develop it without obesity or diet as a contributing factor. At least in the US. That ratio is higher in countries with less obesity. For example just getting old is a major contributor too, as well as just genetic predisposition.

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anonprogtada t1_j0yrw5n wrote

In the 70s total diabetes as a measure of population was 1%. Its now over 10% and can you guess what type has been the main "lifestyle" disease?

Type 1 was never a death sentence. The original "treatment" was ... low/no carb in the 1800s.

But that's besides the point, Diabetics are never even told that they can restore insulin sensitivity and/or put the disease into remission. Its just more pills and injections.

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elijah112358 t1_j0yu7k6 wrote

it’s impressive how inaccurate you’re able to be in so few comments!

There’s a reason we regularly do pre-diabetes screening and education… and why we focus so much on lifestyle changes during the reversible period of T2DM.

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anonprogtada t1_j0yuqfx wrote

Reversible period? If pancreatic function is still present, its a question of restoring insulin sensitivity. Which is still best achieved wth ... low carbohydrate diets. Turns out the thing which overloaded the system aka glucose is the same thing we can remove from the diet to restore it.

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elijah112358 t1_j0ywe8d wrote

No one’s arguing against low carb diets being effective in managing T2DM. However, your assessment that eliminating sugar from a diet will reverse T2DM is only accurate in early stages of the disease.

At some point, insulin insensitivity cannot be reversed with lifestyle changes alone, and is certainly not “best achieved” with such changes.

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anormalgeek t1_j0yvea5 wrote

Again, flat out untrue. Until the isolation of insulin by Banting and Best, the best you could do was extend life. Cutting carbs alone would give you a few months or a couple of years if your "honeymoon period" lasted longer. Because even fat/protein intake affects blood glucose (to a lesser extent than carbs), many people also followed the "starvation diet", which extended life longer by consuming the absolute bare minimum of calories. It always resulted in death though.

Yes, as I clearly implied, type 2 prevalence has increased a lot due to lifestyle but it has always been more prevalent than type 1. Another major contributing factor is age and people are living longer.

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anonprogtada t1_j102adx wrote

Seriously? Here's some FaCts:

Type 2 diabetes accounts for approximately 90% to 95% of all diagnosed cases of diabetes; type 1 diabetes accounts for approximately 5-10%

Source: https://www.cdc.gov/diabetes/basics/quick-facts.html

And type 2 diabetes can be put into remission at any stage of the disease, or do you think there is only one path: ever increasing insulin shots, amputation and death?

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anormalgeek t1_j10kfhj wrote

Again, none of that in any way contradicts what I said earlier.

To quote you directly:

>Diabetes used to be...almost exclusively T1.

I'm talking about that part. Type 2 has ALWAYS been the more prevalent type. Always.

And no, it absolutely cannot be put into remission for all patients. There are some people with completely healthy diets, weights, and exercise regimens that still develop the disease. They are absolutely the minority. I am not disputing that. But you're flat out wrong to claim that doesn't happen. Or that type 1 used to be more prevalent than type 2. Or that people could survive long term with type 1 with lifestyle changes alone before insulin was available. Those are all 100% incorrect statements that you've made.

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