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Whites11783 t1_ixuw07s wrote

Reply to comment by H2AK119ub in Brain cancer vaccine succeeds at prolonging survival in Phase 3 trial by Sorin61

Yeah, I was going to say, tough to not offer crossover to that patient population

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klipseracer t1_ixuy7av wrote

I presume that means to offer them the medication at some point instead of a placebo?

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H2AK119ub t1_ixv0sac wrote

It's effectively a single arm, uncontrolled trial; all patients involved in the "placebo" eventually cross over to the treatment arm. The investigators of the trial state that extracting DC's from GBM patients with poor prognosis is unethical without providing treatment.

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