Lived in STL for 7 years and relocated back to Springfield a few years ago while still working remotely for a company there.

If you're living in a larger city, you will miss things like good grocery stores, restaurants, and other attractions that larger cities bring. Real estate is cheaper when you compare what you are actually getting for your money.

I personally wouldn't count on finding a local job if you are planning to get laid off. Springfield has substantially less jobs compared to metros like KC/STL.