Yes and no, In an interstellar or intergalactic trip you would need to go by way points along the path. At each way point you would need to recalculate your journey based on your location and things that have changed in your path. Over that huge span of time there would be events like supernovas, stellar collapse, black holes, etc.. that might occur and force course corrections. The expansion of the universe is a bit of a constant so it would not be too much of a variable depending on the distance and time traveled. It would be in the consideration, but at each way point would be reset naturally.