At 50000mph (a bit over 22km/s) you wouldn't see anything moving. (Well, unless you encountered a micrometeorite at that speed. Then you would probably see something, but it wouldn't be fun).

You really only see anything changing on appreciable timescales once you're very close to your target.

Really visible effects during flight would only happen if you could get close to the speed of light (300000km/s), where light from stars ahead of you would be blue shifted and light from stars behind you would appear red shifted. You'd also get some weird distortion effects in front and behind.

...but if you encounter even a grain of dust at those speeds you're in for a very bad day.