I am sure of a few things.

We are not alone in the universe.

I am sure that civilizations have risen and fallen everywhere. There are some places where unicellular life is just beginning, some places where life has just begun to emerge onto land, somewhere there are people who are the equivalent of us currently and doing the exact same thing, and somewhere is 100K years ahead technologically.

There is also life that we can't explain. Silicon based, gas based, life on a subatomic level.

There is life that we can't see. They exist in infrared or ultraviolet. They exist in gamma. Perhaps in radio waves.

There are beings of light, beings of time, beings who live on a scale that we can't even comprehend.

There is also a multiverse where infinite yous are doing slightly different things at slightly different times, where the differences create an entirely new timeline for that particular you.

There is also somewhere where other you and other me are having this exact same interaction.

I think we are all too far apart in spacetime to interact. We may find unicellular and bacterial life in our system, maybe even fish-type life on Io or Ganymede. I hope so.