Well it's unfortunate that you have such a poor grasp of thermo despite spending 8 years working toward a PhD, but I guess you'd be the secon\\d idiot on reddit that I've seen arguing incorrectly about the thermodynamics of the cell. I suggest you go and review first year physical chemistry. You remind me of a clown similar to you over on r/biochemistry arguing against the other users about whether the cell is a closed system.It's also a little funny that you resort to insults because you get so easily flustered explaining your misunderstandings with poor analogies. No one is confusing the difference between metablism and ageing. However you seem to be confused about the difference between cell growth and ageing. Cells grown and maintain themselves. This requires free energy which is derived from the decrease of free energy in molecules like glucose, producing simpler CO2. This results in an increase in the entropy of the surrouning environment and a decrease within the cell. As cells age the ability of the cell to maintain itself decreases, barring senescence we don't know the precise mechanism of why, but it results in increased entropy within the cell. Eventually the cell is unable to maintain itself and dies afterwhich it rapidly increases in internal entropy to a point equivalent to it's surroundings.

,,iMpErfecT uPkeEp/mAinTEnance mEchaNisms'' occur because the cell increasingly loses its ability to resist the increase of internal entropy. That is ageing. That is quite different from growth and development which occurs, not because of dysregulation, but because of normal, regulated gene expression, with no notable change in internal entropy. I find it amazing that you think 'imperfect maintenance of the organism’s existing structures' lead to maturation from an infant to a teenager. And that normal growth is equivalent to a 40 year old growing into a 90 year old with liver spots and cancer.

If you would give a comparison like the development of larger muscles during puberty to the onset of diabetes or male pattern baldness then I could see where you're coming from and say that is probably an example of antagonistic pleiotropy but instead you liken it to hearing loss and back pain.

Here's a paper that discusses it further. I'm guessing you won't read cuz you seem like the type to only read you own research and laugh at your own jokes. Here's a notewrothy quote: "The mechanistic linkbetween entropy generation and pathogenesis has been confirmedin metabolic diseases (simple obesity, diabetes, metabolic hypertension".

And here's a list of other research showing the link between ageing and entropy.

You yourself said exactly what I've been trying to explain in your first comment:

>Aging is a product of imperfect upkeep/maintenance mechanisms.
>
>Entropy is why maintenance is required in the first place

Then you go on and contradict yourself repeatedly.

Actually it's also kinda funny you said 'entropy is disorder' in a debate while unironically calling yourself a scientist. Or that you described a closed system as only being able to maintain its internal entropy, when, by definition, it will maintain the same entropy or increase it. What a joke.