You will not be able to distinguish between a game and real life. This will happen in a not so far future.

Future games and simulations will be so immersive you will expect to respawn IRL. You will eventually be able to respawn IRL. You and your life is at this point a game and you are a super hero. This in turn allows us to connect our minds directly with others and AI, you will experience all kind of sensory input that your biological body can not, such as being a swarm, a body scattered in space and time.