Shape of a protein predicted by two different AI models (ESMFold on the left, AlphaFold on the right)cat3cat123 t1_iw6b63i wrote
Reply to comment by Talkat in Shape of a protein predicted by two different AI models (ESMFold on the left, AlphaFold on the right) by greentea387
It’s not a copy. Completely different architectures. ESMfold uses a language model while AlphaFold2 does not. ESMfold can predict on a single sequence, and AlphFold2 works best when you give it multiple related sequence in a multiple sequence alignment. ESMfold is also way faster (though not as accurate than AlphaFold2)
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