Submitted by Ezekiel_W t3_y1h2tt in singularity
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ihateshadylandlords t1_irxo1cc wrote
> In future studies, Siegwart and his team are hoping to find more ways to use this new CRISPR delivery technology, including in conjunction with existing therapies. “This study…demonstrated the ability to combine multiple therapeutic agents in one nanoparticle. Therefore, we would like to use this strategy for other tumors that have similar measures to their matrix barriers and try other diseases that also have physical barriers, like fibrosis models,” Siegwart said.
Interesting. Excited to see how this plays out.
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gibecrake t1_irxpkcv wrote
I'm actually surprised CRISPER hasn't made even more groundbreaking breakthroughs. I think we might see a different story once someone decides to pair it with some of the newer AI models. Watch me cry sarcastic tears as the pharma industry dries up.
Ezekiel_W OP t1_irxtiqr wrote
CRISPR is continually making breakthroughs, posting all of them would mean posting almost every day with updates, which I am too lazy for.
Mooblegum t1_irycfgq wrote
For daily info about it r/CRISPR
arevealingrainbow t1_iryh42x wrote
The #1 reason CRISPR isn’t as transformative of a technology as it should be is because the FDA is stuck in the 20th century.
rredirt t1_irzz9rg wrote
Who do you think is getting all the patents and is paying for all of these breakthroughs? Pharma will not own directly those patents but will always owns the mean to the product and compounds productions.
-ZeroRelevance- t1_is0d8rb wrote
The mad scientist in me kind of wants them to completely get rid of the regulations and see how much faster we would be able to advance
XXX_MemeSlayer_XXX t1_is2wm42 wrote
[deleted] t1_is4wuz3 wrote
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Ezekiel_W OP t1_irxairn wrote
>In a paper recently published in Nature Nanotechnology, Siegwart and his team developed a dual approach using LNPs equipped with tools that allow them to access and modify the tumor.4 The researchers packaged the LNPs with a CRISPR-Cas9 system that genetically modified and disrupted PD-L1 gene expression. PD-L1 overexpression inhibits T cell infiltration within the tumor microenvironment, so deactivating the gene allows immune cells to access the tumor. To grant the CRISPR system and immune cells tumor access, the LNP also included siRNA that targeted and reduced the expression of focal adhesion kinase (FAK), which diminished the density of the extracellular matrix surrounding the tumor.