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userbrn1 t1_ir1mxjl wrote

Reply to comment by ZoomedAndDoomed in New Alzheimer’s drug slows mental decline by 27% in clinical trial by Shelfrock77

We've always known (for several decades at least I believe) that amyloid proteins contribute to Alzheimer but we still aren't sure to what degree, since it's almost certainly a multi-factorial pathology

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joe0185 t1_ir2eq5a wrote

>We've always known (for several decades at least I believe) that amyloid proteins contribute to Alzheimer

From what I understand, what we've always known is currently being called into question.

  1. A lot of the research was faked.

  2. The drug Aduhelm reduces beta-amyloid plaques in the brains of people with Alzheimer's disease but does not improve cognition nor slow progression. Which also calls into question the amyloid hypothesis.

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userbrn1 t1_ir2is90 wrote

This drug in the OP also works on AB-amyloid and does appear to slow mental decline, but it allegedly does so by inturrupting the formation of new AB-amyloid by binding its precursors rather than trying to reduce already existing amyloid plaques. If these results hold then it further strengthens the amyloid theory.

I think that first article you posted exaggerates the degree to which the research was faked; independent biochemical testing was performed by more than just the scientists in question in the article and the amyloid theory continues to prove fruitful

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