im really sorry you struggle with this too. You're not alone. It's been really nice talking to GPT about it a little. So far phenibut and yellow vein kratom was the most effective but they're definitely not suitable for daily or near daily use, and both have their own dependency issue risks.
I'm sure there will be substances AI helped synthesize that were narrowed down from long lists of different substances depending on their theoretical receptor activity. I guess we'll see.