ArandomFluffy t1_j4v02y5 wrote
Reply to comment by exileonmainst in First proof of concept for editing a gene that causes heart disease, by modifying two letters — a therapy that would be applied once and last a lifetime by marketrent
from the article: >We packaged the ABE components in adeno-associated virus serotype-9 (AAV9) using a split-intein trans-splicing system to accommodate the large size of ABE8e and sgRNA6. AAV9 was chosen as the delivery system because it effectively infects the hearts of mice and large mammals (2, 4). To ensure cardiac specificity, we used the cardiac troponin T (cTnT) promoter to drive ABE8e expression.
Viewing a single comment thread. View all comments