Kakkoister t1_j4ty77d wrote on January 18, 2023 at 5:53 AM

Reply to comment by exileonmainst in First proof of concept for editing a gene that causes heart disease, by modifying two letters — a therapy that would be applied once and last a lifetime by marketrent

As other have mentioned, virally at the target location (heart cells last a lifetime). But also, you don't need to replace all the DNA. Just a decent majority to quell the expression of those genes.