LizzieButtons t1_j4c9ahj wrote on January 14, 2023 at 6:12 PM

Reply to comment by Ghede in Alzheimer’s tied to cholesterol, abnormal nerve insulation by D-R-AZ

If the issue is that cholesterol is not channeled where it can be made in myelin sheath then the problem isn’t too much cholesterol, its that the cholesterol is being sequestered in the wrong place. The effects of lifestyle changes will not eradicate that problem and an argument that diet and exercise are better than medication may be flawed. I’m a layman, just trying to understand the publication.

iamorangeyblue t1_j4fp0v5 wrote on January 15, 2023 at 11:25 AM

You understand it well. I am a little frustrated that others haven't read the article or bother to understand. To put it simply, bad gene means not enough cholesterol protecting the neuron's connections. Less cholesterol isn't the answer here, more is needed in the right place, as you say.