090810290202 t1_j0nwh64 wrote
Reply to comment by Haunting-Offer6922 in Cambridge scientists have shown that a widely-used drug to treat liver disease can prevent SARS-CoV-2 infection or reduce COVID-19 severity by hot
Yeah, interestingly Moderna is suing phizer/BioNTech over the delivery mechanism. Allegedly they are very similar/same from what the news article claimed.
I’m sorry you went through that. The vaccine kicked my butt, but I’m glad I got it. Covid kicked my butt even after the vaccine. It could have been worse. My wife and kids we’re vaccinated and covid was like a weak cold for them. No issues.
ChronWeasely t1_j0omyk1 wrote
Must have to do with stability. The basic delivery mechanism is not uncommon for new mRNA treatments. One of several. Lipid stabilization, which lets it enter cells by just merging with cell walls, which are also lipid, and dumping the mRNA inside. As the mRNA doesn't need to go any further in the cell, that's all that's needed.
Some more complicated ones have several components to navigate each part of the delivery mechanism.
090810290202 t1_j0pe453 wrote
Indeed! I believe the narrative was that Pfizer/BioNTech tried out 3 or maybe 4 mechanisms in clinical trials and ultimately went with the one patented by Moderna.
I assume they utilized different adjuvants and strengths.
Complex_Experience83 t1_j0pbl69 wrote
I’ll probably get banned for saying this, but I’m so curious to the people that say covid was bad for them and it would have been worse if they weren’t vaccinated if that would actually be true. I hear this so often. Maybe the vaccine didn’t actually have the impact it was supposed to. No way to really know but
KingKudzu117 t1_j0phi1j wrote
Yes there is a way to know. It’s called the scientific method. The original lineage of CoV2 was extremely bad. Our immune systems were not able to mount a sufficient response without significant viral load. The vaccine saved hundreds of thousands of lives and prevented serious illness in millions. There’s a significant disinformation campaign out to revise history and discredit the vaccines. https://www.factcheck.org/2022/08/scicheck-widespread-claims-misrepresent-effectiveness-of-covid-19-vaccines/
TheTrueSleuth t1_j0pp37i wrote
you're not gonna believe me but my whole family, mother father and brother, have never been vax'd and all got the Alpha version and fought it off fine.
jamehthebunneh t1_j0prdd6 wrote
The plural of "anecdote" is not "data".
wtgreen t1_j0ps6dn wrote
I had covid twice before vaccines were available and it was generally mild... I continued working - from home - and even was able to workout most of the time, though I definitely had some trouble catching my breath.
Just because your family and I had no trouble from covid doesn't dismiss the huge numbers of people that did, and it's that massive impact world-wide that qualified it as a health emergency. My daughter worked in ICUs around the country during covid. She shared the awful despair she saw daily. Places were overwhelmed and PPE, staff, bed and equipment shortages made the suffering worse, as did coworkers and colleagues getting sick and turning into patients. Yeah... my experience was mild and it was for many, but that doesn't change the fact that millions died world-wide.
TheTrueSleuth t1_j0s2f2w wrote
I didn't say it changed that fact but that doesn't mean it's a death sentence by any means any more than the flu. Some people just have better stock. Stronger, apparently. I cannot explain it.
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