>In this study, the results showed that the low efficacy of preventive measures for preventing infection in unvaccinated people does not necessarily mean that they are completely ineffective. As an example, our results show that protective measures on non vaccinated individuals were statistically significant in reducing the need to receive anti-COVID-19 treatments (OR: 0.447, 95% CI = 0.321–0.623; p < 0.0001). These agree with the systematic review of Talic et al., who found a reduction in the incidence of COVID-19 associated with mask-wearing, handwashing, and physical distancing.