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dragonfaith t1_j1244h4 wrote

Not clear why the study design is atypical re dosage and duration of administration of the drugs. Normally, kids are given NSAIDs only when in pain or sick - fewer than, e.g. 3-4 low dose administrations a month, if that.

"celecoxib (n = 20) or indomethacin (n = 20) treatment for a period of 28 days or received no medication (control group, n = 20). "

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Swellmeister t1_j12kwne wrote

Celecoxib is commonly prescribed for juvenile arthritis and indomethacin is commonly used for a congenital heart defect (PDA) prior to surgery. Long-term daily use is the expected dosing for those indications. You aren't typically getting a prescription of these for a headache after all.

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