peoplerproblems t1_iw77u4e wrote on November 13, 2022 at 2:25 PM

So what makes this work differently than a GLP-1 agonist? everything hear sounds like this is another potential weight-loss drug by a well known mechanism

1saltymf t1_iw9vgi9 wrote on November 14, 2022 at 1:23 AM

> These NPF-induced changes in food intake were likewise not associated with altered triacylglyceride (TAG) or circulating sugar levels (Extended Data Fig. 1l,m), supporting a direct role for gut-derived NPF in governing feeding behaviour, rather than effects of NPF on metabolism that then lead secondarily to altered behaviour. Together, these results indicate that NPF from these EECs is both necessary and sufficient to inhibit food intake and prevent food overconsumption.

GLP-1 agonists alter insulin patterns and average blood sugar, in addition to appetite suppression and modifying feeding behavior.

Seems like this drug, analogue to NPY in humans, mainly affects feeding behaviors.