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Ah, The Marijuana Herald. Move over, New York Times.

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Here, maybe this will satisfy you instead.

https://www.ncbi.nlm.nih.gov/books/NBK556048/

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I’m not op and the study I linked was last updated July 2022.

The study the article links to was published by the National Institute of Health four days ago

https://pubmed.ncbi.nlm.nih.gov/36417631/

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Thanks for the link. Decent study. As with most cannabis research it shows real but small benefits that are not broadly generalizable. The take home is that for most people marijuana is purely recreational. If you happen to have tuberous sclerosis, it’s marginally good news.

Some veterinarians are suggesting it for dogs with seizure conditions. It seemed to drastically reduce seizures for a family dog in the last few years. From 2 or 3 a day to once or twice a month.

Wasn't an entire strain called "Charlote's Web" developed to help with epilepsy?

NCBI is part of the national library of science…

Don't just attack the messenger. Of course, one should question potential bias. But always look at the source of the data.

Which, as others have pointed out, is 100% legit, scientifically speaking. :)

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I have a small Pomeranian that has seizures that last for 10 to 20 minutes. I can squirt a tiny amount of CBD mixed with MCT oil into his mouth and he calms down within 2 to 3 minutes and has fewer side effects from a prolonged seizure.

I have a dog that's had pretty severe epilepsy for the last 7 years. We've had her on 5 different epilepsy drugs, and eventually settled on a specific mix that seems to work well for her.

We considered CBD, but a medical dosage of it is insanely expensive compared to traditional drugs. This article (and the paper's abstract) doesn't mention the doses used in this study.

Isn’t epidiolex already a prescribed medication? Meaning we already knew it was helpful?

If you live in a legal state, or Canada, go buy CBD oil from a dispensary. CBD oil is CBD oil.

... We've known that for decades...

Yes, research done in order to confirm and reinforce what other research has already implied is a common and necessary thing.

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It’s basically the reason weed was made legal for medical purposes.

some exclusions may apply

Yep. It’s it’s a FDA approved CBD derivative, but further research is always a good thing.

The NIH isn't the publisher of these studies. PubMed is effectively just a search engine for a wide range of documents. The NIH isn't affiliated with the studies PubMed hosts, so there are also occasionally studies on it of questionable repute. That being said, PubMed is still a great source of accurate studies and I have no opinion about this particular study. I just think the affiliation with the NIH needs to be clarified.

Edit: looking at the article's citation, it looks like this study was published by the Journal of the Brazilian Medical Association.

1000% anecdotal, but my dog developed seizures in the last 18 months. Despite treatment, they were increasing in frequency, to the point that she had 8 seizures in the month of August. We asked the vet about CBD, they said "it can't hurt," so we bought a vial and have been giving her 2 doses a day. She's had one seizure since she started it almost 3 months ago. To go from 8/month to 1 over 3 months is honestly remarkable.

How much does it cost there?

CBD oil typically costs $0.10 per mg doesn’t it?

Medicinal doses are about 2 mg per pound, twice per day. So for your 70 pound dog that’s a cool $800 a month. Too much money for us.

Yep; plus it’s only currently FDA approved for TS, Dravets, and Lennox Gastaut. I can’t prescribe it to the vast majority of my patients :(

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I'm considering this for my dog as well. Has been having seizures since September, last week he had a 1.5 hour long seizure as we drove him to the nearest animal hospital.

The meds are helping, but he does have breakthroughs.

CBD works for most patients up to 18 months on average. Then in some patients tonic seizures will come back. 1:1 THC CBD solutions address seizures near on completely.

I had the pleasure of welcoming Dr Evan Lewis, a Canadian paediatric epilepsy specialist at a medical cannabis conference I was working. There are children in the UK that have been on epidiolex, GW’s CBD product, who have shown a level of regression, after a couple years on it. They need a whole plant extract, and many who aren’t with the private clinics, or on Project Twenty21 struggle.

If you’re based in the UK and are struggling with access or affordability of medical cannabis, please refer to Project Twenty21 https://www.drugscience.org.uk/twenty21/

You can buy pure CBD crystals on many online stores for 10 dollars a gram or less. I do this and make my own oils for my dog and it makes it incredibly affordable.

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One of the really big issues around CBD and it’s ability to reduce seizures is the fact that it’s always taken with other antiseizure medications (ASMs) in studies. Now, on the surface, this isn’t a problem for most ASMs, until you realize that CBD has a very potent effect on CYP enzymes, which many ASMs are metabolized by. As a result, the increased bioavailability of antiseizure medications is seen when CBD is administered. Does this have an impact on seizure outcomes? Are we inappropriately assuming CBD has a direct antiseizure effect? Unfortunately many of these studies can’t address that question.