WilyStylyMethody t1_iv6h1xu wrote
Reply to comment by a_stoic_sage in BRAIN SEROTONIN RELEASE IS REDUCED IN PATIENTS WITH DEPRESSION: A [11C]Cimbi-36 PET STUDY WITH A D-AMPHETAMINE CHALLENGE. - Biological Psychiatry by chilladipa
I believe the most recent one I read posited that while it was unclear whether or not Serotonin re-uptake had a meaningful effect on depression, that there was still a change in neuroplasticity that made it easier for the brain to rewire(or repair?) certain neural pathways, which in turn made it easier for the patients to eliminate certain negative patterns associated with their depression.
a_stoic_sage t1_iv6hp67 wrote
Can't placebo effect rewire or repair certain neural pathways? If you think you are feeling better, you are rewiring your brain?
westderecho t1_iv76y9b wrote
SSRIs exert a neurogenic effect on the hippocampus and increase the amount of neurotrophic factors there, and also alter the count/ratio of certain serotonin receptors.
To my knowledge this behavior isn't readily found in placebo trials when comparing against SSRIs, and a placebo would not be able to target a certain region.
WilyStylyMethody t1_iv6js8e wrote
That I'm not sure of. Hopefully someone more knowledgeable can chip in here.
Viewing a single comment thread. View all comments