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DooDooSlinger t1_iutdzzc wrote

Reply to comment by ProfessionalHuman260 in New study links suffering from long-lasting severe depression to reduction in brain volume by nikan69

Cortisol is absolutely not established as the cause of depression.

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ProfessionalHuman260 t1_iuu74pf wrote

Cortisol is established as a factor in brain volume. -- By "cause and symptom" I was paraphrasing it's permissive, suppressive, stimulatory, and preparative actions in association with the stress response (see Sapolsky, 2000). Cortisol has strong and well known association the acute and severe Major Depressive Disorder. While cortisol hypersecretion does not sufficiently explain the nature of depression, it is a contributing cause that continues to have maladaptive feedback, potentiate nueral pathways, and impair corticosteroid receptors throughout the depression furthering the severity.

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guave06 t1_iuv17u7 wrote

That would mean athletes are highly depressed population. instead we see the opposite

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