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Euda-monia t1_itfz5bs wrote

Reply to comment by dv_ in Association between triglyceride-to-high-density lipoprotein cholesterol ratio and prediabetes: a cross-sectional study in Chinese non-obese people with a normal range of low-density lipoprotein cholesterol | Journal of Translational Medicine by Meatrition

That's part of the picture, yes. There are still a lot of unknowns but what we do know is that both the glycation and oxidation of LDL reduce its ability to be recognised for recycling by the liver. Higher circulating LDL means higher risk of it entering into the artery wall where macrophages gorge on them resulting in foam cells.

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dv_ t1_itg8h7x wrote

When the macrophages pull in the damaged LDL particles, do they ever go away? Are there self-repair mechanisms in the body that clean that up over time?

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