cultureicon t1_ita81l1 wrote on October 22, 2022 at 2:03 AM

Reply to comment by davidmartin1357 in Using a gel-like, radioactive implant, engineers have demonstrated the most effective treatment for pancreatic cancer ever recorded in mouse models, the new treatment completely eliminated tumors in 80 percent of mice across several model types, including those considered the most difficult to treat by giuliomagnifico

Looks like they can inject them with a number of chemicals, or use genetic engineering:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995380/

Rat: Wistar and Lewis rats are injected intraperitoneally with azaserine to induce acinar cell carcinoma of the pancreas, with liver, lung and lymph node metastasis 6, 7. However, the lesions in this model lack a typical duct-like structure and of ten occur alongside tumors of other organs (mammary, liver, kidney). The chemicals 4-hydroxyaminoquinoline-1-oxide 8, nafenopin 9, clofibrate 10, N -(N-methyl-N-nitrosamide)-L-ornithine 11 and different N-nitro compounds 7 can induce acinar cell lesions without a duct-like structure. Vesselinovitch et al. found that topical benzopyrene can induce adenocarcinoma in rats. They implanted dimethylbenzanthracene crystal powder into the pancreas of Sprague-Dawley rats, and approximately 80% of them developed spindle cell sarcoma and poorly differentiated adenocarcinoma. Other researchers using this method have found ductal cell proliferation, tubular adenocarcinoma, acinic cell carcinoma, fibrosarcoma, and invasive ductal adenocarcinoma.

davidmartin1357 t1_itaafgr wrote on October 22, 2022 at 2:23 AM

Thank you so much for the answer

Bobdolezholez t1_itam9k0 wrote on October 22, 2022 at 4:14 AM

Do studies ever focus on those 20% of mice that don’t develop cancers after injections and why that might be?

1-trofi-1 t1_itb1dhh wrote on October 22, 2022 at 7:19 AM

Yes this is what they do. Each method has its own advantages and disadvantages regarding how representative it is to human disease