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triffid_boy t1_ithkgw0 wrote

Reply to comment by sfzombie13 in Research shows stem cell-derived neurons from combat veterans with and without post-traumatic stress disorder (PTSD) provide insights into how genetics can make someone more susceptible to developing PTSD following trauma exposure by Wagamaga

The studies are not on the people, they're trying to identify genetic targets and generate models to use in vitro. It's completely valid.

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sfzombie13 t1_itiegsp wrote

no, but they're using people. that's where the genes come from, and with only 39 of them, and all of them vets with ptsd, how do they know they have enough of a diverse sample to make any meaningful connections that can't be explained by chance?

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triffid_boy t1_itih0qo wrote

A reasonable case is given through the other studies in the paper to be honest, e.g demonstrating that they have similar transcriptomic signatures to post mortem brains with PTSD.

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